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The bottom line seems to be that any method of weight loss, whether it is lifestyle modification or medical intervention, needs to be sustainable

Weight loss is a well-documented effect

Patients pay month to month, which gives them flexibility to pause or cancel if the medication is not working or if they experience intolerable side effects

The PI3K inhibitor parsaclisib ameliorates pathology and reduces autoantibody formation in preclinical models of systemic lupus erythematosus and Sjgrens syndrome

*These medications are typically recommended in combination with lifestyle changes like a reduced-calorie diet and exercise, under the guidance of a healthcare provider